SELECT 
  pfv.feature_id, 
  pfv.product_id, 
  pfv.variant_id, 
  fv.position, 
  fvd.variant 
FROM 
  cscart_product_features_values AS pfv 
  INNER JOIN cscart_product_feature_variants AS fv ON pfv.feature_id = fv.feature_id 
  AND pfv.variant_id = fv.variant_id 
  INNER JOIN cscart_product_feature_variant_descriptions AS fvd ON pfv.variant_id = fvd.variant_id 
  AND fvd.lang_code = 'en' 
WHERE 
  pfv.feature_id IN (
    21622, 21150, 21177, 20857, 20509, 21074, 
    24978, 20104, 19955, 24741, 20272, 
    22136
  ) 
  AND pfv.product_id IN (
    23147, 2299, 2231, 20625, 3720, 2441, 
    48873, 5148, 5729, 47008, 4388, 24798
  ) 
  AND pfv.lang_code = 'en'

Query time 0.03226

JSON explain

{
  "query_block": {
    "select_id": 1,
    "nested_loop": [
      {
        "table": {
          "table_name": "pfv",
          "access_type": "range",
          "possible_keys": [
            "PRIMARY",
            "fl",
            "variant_id",
            "lang_code",
            "product_id",
            "fpl",
            "idx_product_feature_variant_id"
          ],
          "key": "idx_product_feature_variant_id",
          "key_length": "12",
          "used_key_parts": ["product_id", "feature_id", "lang_code"],
          "rows": 146,
          "filtered": 0.037544265,
          "attached_condition": "pfv.feature_id in (21622,21150,21177,20857,20509,21074,24978,20104,19955,24741,20272,22136) and pfv.product_id in (23147,2299,2231,20625,3720,2441,48873,5148,5729,47008,4388,24798) and pfv.lang_code = 'en'",
          "using_index": true
        }
      },
      {
        "table": {
          "table_name": "fv",
          "access_type": "eq_ref",
          "possible_keys": ["PRIMARY", "feature_id"],
          "key": "PRIMARY",
          "key_length": "3",
          "used_key_parts": ["variant_id"],
          "ref": ["dev_db.pfv.variant_id"],
          "rows": 1,
          "filtered": 100,
          "attached_condition": "fv.feature_id = pfv.feature_id"
        }
      },
      {
        "table": {
          "table_name": "fvd",
          "access_type": "eq_ref",
          "possible_keys": ["PRIMARY"],
          "key": "PRIMARY",
          "key_length": "9",
          "used_key_parts": ["variant_id", "lang_code"],
          "ref": ["dev_db.pfv.variant_id", "const"],
          "rows": 1,
          "filtered": 100,
          "index_condition": "fvd.lang_code = 'en'"
        }
      }
    ]
  }
}